Go into the Amarra preferences. At least with Audirvana I have to manually select a new DAC when I plug it in.
Pretty much this. And I agree with the comments about finicky mac USB in general. I use a Schiit Wyrd just because it can be so inconsistent. I'll add one (possibly) helpful comment: for me at least, it helps things if I don't have the source that I want to use set in Mac OS System Preferences. Audirvana and JRMC both have application exclusive access (or, "Hog Mode") built into the program, so they'll use whatever source selected in the program regardless of what is set in Mac OS preferences. I'd imagine that Amarra has that too. Sometimes when switching DACs out that exclusive mode setting conflicts with the Sound Output OS settings. I leave my Sound Output OS settings on "Internal Speakers" and only select external audio devices inside of the options of the particular program I'm using. This prevents device/application conflicts.
A very different question (maybe belongs in the Yggy thread).... Over the weekend I was going back and forth between my MBA --> Xfi --> LCD-X on one hand and the MBA -->Yggy--> Mojo --> LCD-X. After using the Xfi, when I went to the Yggy, there was no sound output (and more importantly) the bit rate lights were not lighting up. The first time, I shut down and restarted the MBA and everything was fine with the Yggy. The second time, the same procedure did not work. I shut down the Yggy for like 5 seconds and turned it back on. Everything was fine again...I'm using Amarra 3.0.3 on the MBA. Any thoughts would be helpful and apologies if this does not belong here...
I saw this once with my Yggy, working against a Mac mini running Audirvana. Restarted Audirvana, didn't matter. Attempted playback to other USB DACs, worked fine. Rebooted the mini, which I was sure would solve the problem, no dice...Power-cycled the Yggy: bingo.